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KMID : 1094720170220010045
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Biotechnology and Bioprocess Engineering
2017 Volume.22 No. 1 p.45 ~ p.51
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Polysaccharides isolated from liquid culture broth of Inonotus obliquus inhibit the invasion of human non-small cell lung carcinoma cells
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Lee Jong-Seok
Lee Ki-Rim
Lee Sa-Rah
Lee Hye-Jin
Yang Hee-Sun
Yeo Joo-Hong
Park Jun-Myoung
Choi Byung-Hyun
Hong Eock-Kee
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Abstract
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Polysaccharides isolated from Inonotus obliquus (PLIO) have been known to have various pharmacological activities including antioxidant, immunostimulating and anti-tumor activity. However, the anti-metastatic effect of PLIO in human non-small cell lung carcinoma (NSCLC) has not been elucidated. In this study, we investigated the effects of PLIO on the metastatic potential of human NSCLC A549 cells and its underlying mechanisms. PLIO suppressed the invasive potential of A549 cells throughout reducing matrix metalloproteinase (MMP) expression. PLIO treatment inhibited NF-κB nuclear translocation in A549 cells. In addition, PLIO treatment inhibited the phosphorylation of JNK/AKT in A549 cells. These results suggest that PLIO could inhibit human NSCLC invasion via suppression of AKT/NF-κB signaling pathway.
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KEYWORD
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PLIO, polysaccharides, NSCLC, anti-metastatic activity, AKT/NF-κB
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